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Clinical Laboratory Manager

Details
  • Location

    Guildford, UK

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About ANGLE

ANGLE is a world-leading liquid biopsy company commercialising a patent protected platform technology that can capture rare circulating tumour cells (CTCs) from blood, in a minimally invasive way, for downstream analysis.

ANGLE’s Parsortix® system is FDA cleared for its intended use in metastatic breast cancer and is currently the first and only FDA cleared medical device to harvest intact circulating cancer cells from blood. Parsortix technology comprises a microfluidic device that captures CTCs from blood based on their size and compressibility. CTCs are cancer cells that have detached from the primary tumour and entered the blood circulation, and they play a critical role in initiating metastasis. Once harvested, the CTCs can be comprehensively analysed to provide a wealth of information about the patient’s tumour, advancing cancer research and potentially personalized medicine. This technology has the potential to deliver profound improvements in clinical and health economic outcomes.

ANGLE has established a CTC harvest and analysis service from our UK-based Clinical Laboratory based in Guildford for customers worldwide. In alignment with company priorities, we plan to rapidly expand our services to include molecular profiling of CTCs and ctDNA using digital PCR and NGS to add to our image-based assays.

Join our Team

This is an exciting time at ANGLE and our team in Guildford are looking for a Clinical Laboratory Manager. The Clinical Laboratory Manager will oversee operations in the clinical laboratory in, this will include co-ordination of the daily work schedule and instruments, ensuring that clinical samples are processed according to Standard Operating Procedures, and in compliance with all applicable regulations.

At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading-edge translational research into clinical diagnostics. We promote a culture of collaboration and shared excellence while encouraging an open and honest exchange of ideas.

We are always in search of potential employees who share our vision and want to make a difference today. In your submission, please describe your background and what you can bring to our team along with attaching your resume.

Principal Accountabilities

The Clinical Laboratory Manager will manage the Laboratory Information Management System (LIMS), ensuring seamless data flow and integration, maintaining system compliance, and overseeing the efficient use of LIMS for all laboratory operations according to internal quality management system procedures.

This includes ensuring compliance with regulatory standards and internal protocols for data integrity, traceability, and security. The Clinical Laboratory Manager will also manage the automation of data workflows within LIMS and support the upkeep of quality system documents as part of ongoing quality control and compliance efforts.

Duties will include:

  • Supervise daily clinical lab operations
  • Responsible for co-ordination of the daily work schedules
  • Coordinates availability of reagents and instruments to ensure smooth daily operations and customer satisfaction
  • Liaise with other departments across the company to ensure all workflows operate efficiently
  • Ensure compliance with H&S
  • Ensure quality and regulatory compliance with CLIA / ISO15189, GCP, GCLP and all other applicable (internal and external) regulations and requirements
  • Assist in hosting internal and external audits as needed and support the implementation of corrective actions to help ensure continuous compliance and improvement
  • Work with the Head of Clinical Laboratories to establish the laboratory’s quality management system and assist in the implementation and successful day to day operation of such to maintain quality laboratory practice standards
  • Maintain the LIMS system, ensuring the timely and accurate entry, tracking, and reporting of laboratory data, while adhering to data integrity principles
  • Take responsibility for LIMS configuration, customization, and troubleshooting, working closely with external vendors or internal support as needed
  • Support the ongoing review and improvement of laboratory SOPs and assist in ensuring effective training and compliance with quality system requirements across the team
  • Undertake additional work activities as required to ensure that the clinical laboratory is running smoothly and delivering client data on time

Education, Qualifications and Experience

  • BSc/MSc/PhD in a biomedical subject
  • Preferably 3 years’ experience of working in a clinical laboratory with a focus on quality assurance and operational management
  • Experience in providing services to customers and maintaining strong relationships
  • Working knowledge of appropriate regulatory requirements (e.g. GCP, GCLP, ISO, CLIA) particularly ISO 13485 and ISO 15189
  • Experience in the management and optimization of LIMS systems, including system programming, database maintenance, and integration with laboratory instruments. Proficiency in standard data analysis software
  • Expertise in maintaining strict quality management standards relevant for clinical laboratories
  • Ability to manage laboratory budgets, ensuring cost control, efficient resource allocation, and adherence to financial and operational targets
  • Strong commitment to producing high quality results in support of project goals
  • Resourceful and able to work to deadlines with accuracy and excellent attention to detail
  • Collaborative workstyle, with a strong ability to build relationships across diverse functional groups and establish credibility with internal customers and/or external partners
  • Ability to recognize and respond appropriately to unexpected opportunities or risks
  • Committed to continuous improvement of processes and/or products
  • Exceptional organisational and time management skills
  • Creative, yet disciplined problem solver
  • Maintains high degree of discretion, integrity, and confidentiality in dealing with clinical samples
  • Strong verbal and written communication skills
  • A flexible, can-do approach to the requirements of the job

Job Requirements:

​Due to the nature of the role, our requirement is for this position to be Guildford based each day.

As a member of our highly skilled team you will receive opportunities for training and development and a competitive benefits package.

Please let us know if you require disability-related accommodation during the recruitment process so that we can work with you to meet your needs.

Furthermore, please be advised that if you submit an application to us for this position, your application and personal details will be processed in accordance with our Data Privacy Notice for Job Candidates.

Important notice to Employment Businesses/Agencies

ANGLE does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact our ANGLE recruitment team to obtain prior written authorisation before referring any candidates. In the absence of such written authorisation being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of ANGLE. ANGLE shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

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