Clinical Laboratory Scientist

ANGLE is a world-leading liquid biopsy company commercialising a patent protected platform technology that can capture rare circulating tumour cells (CTCs) from blood, in a minimally invasive way, for downstream analysis.

ANGLE’s Parsortix® system is FDA cleared for its intended use in metastatic breast cancer and is currently the first and only FDA cleared medical device to harvest intact circulating cancer cells from blood. Parsortix technology comprises a microfluidic device that captures CTCs from blood based on their size and compressibility. CTCs are cancer cells that have detached from the primary tumour and entered the blood circulation, and they play a critical role in initiating metastasis.  Once harvested, the CTCs can be comprehensively analysed to provide a wealth of information about the patient’s tumour, advancing cancer research and potentially personalized medicine. This technology has the potential to deliver profound improvements in clinical and health economic outcomes.

ANGLE has established a CTC harvest and analysis service from our UK-based Clinical Laboratory based in Guildford for customers worldwide.  In alignment with company priorities, we plan to rapidly expand our services to include molecular profiling of CTCs and ctDNA using digital PCR and NGS to add to our image-based assays.

This is an exciting time at ANGLE and our team in Guildford are looking for a Clinical Laboratory Scientist I to play a crucial role in the processing and analysis of blood samples using validated assays that would potentially support the detection of cancer and pre-cancerous features in circulating cells using complex microscopy and other technologies. The job holder will use their expertise to compare normal versus abnormal cell morphology/expression and evaluate the significance of those differences to identify disease in various stages.

At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading-edge translational research into clinical diagnostics. We promote a culture of collaboration and shared excellence while encouraging an open and honest exchange of ideas.

We are always in search of potential employees who share our vision and want to make a difference today. In your submission, please describe your background and what you can bring to our team along with attaching your resume.

• Process and analyse blood samples for circulating tumour cells or other rare events utilising novel and established technologies and methodologies
• Operate immunofluorescence and/or other downstream assays, and run controls as required.
• Provide scientific and technical support to existing and upcoming projects
• Assist in the development and revision of laboratory standard operating procedures (SOPs), quality management and document control, and implementation of new assays
• Collaborate in the training and development of new staff
• Help design experiments, conduct audits, risk assessments, and data analysis.
• Maintain safety guidelines for clinical laboratory environments and regulatory compliance with CLIA / ISO 15189 and all other applicable regulations
• Set up, validate, run, maintain, and calibrate, equipment when required
• Contribute to the smooth running of laboratory facilities; to include but not limited to stock monitoring and purchase, chemical preparation and handling, cleaning/disinfection activities, data entry and revision, other clerical duties as needed
• Support all aspects of Laboratory Management in a variety of tasks both in and out of the lab as when required by the supervisor to include but not limited to laboratory administration and operation support, instrument repair and troubleshooting
• Undertake additional ad-hoc tasks as required

• Expertise in immunofluorescence is desired
• BSc or equivalent with a focus on biomedical sciences, combined with a proven record of clinical laboratory experience, or an equivalent combination of experience and formal education
• Strong scientific and technical aptitudes, and commitment to high quality service combined with tolerance for either unexpected or repetitive work
• Excellent work ethic, and strong liaison skills
• Strong team player with excellent verbal and written communication skillset
• Exceptional organisational and time management skills, with the ability to multitask and prioritise to meet deadlines
• An eye for detail, decent software proficiency, good notetaking and recording practices
• Ability to work both independently with minimal supervision as well as in a team environment
• Possess a flexible, can-do approach to the requirements of the job
• Continuous learner with a keen appetite for cross-disciplinary work

Due to the nature of the role, the job is Guildford-based but integrates an international team.

​You are contracted for a 35-hour working week. Your hours of work will normally be seven (7) hours a day within the period 7.00 a.m. and 7.00 p.m. on a mutually agreed shift pattern.

As a member of the Clinical Laboratories team, you will be required to regularly work weekends (we anticipate this to be approximately 1-2 weekend days per month, on a rotation basis). When weekend work is required, your working week will be adjusted either Tuesday to Saturday inclusive, or Wednesday to Sunday inclusive.

​As a member of our highly skilled team, you will receive opportunities for training and development and a competitive benefits package.

Please let us know if you require disability-related accommodation during the recruitment process so that we can work with you to meet your needs.

Furthermore, please be advised that if you submit an application to us for this position, your application and personal details will be processed in accordance with our Data Privacy Notice for Job Candidates.