Group Leader – Molecular Biology

Guildford, UK

About ANGLE:

ANGLE is a world leading liquid biopsy company with sample-to-answer solutions. ANGLE’s proven patent protected circulating tumor cell (CTC) harvesting technology is known as the Parsortix® system.   ANGLE’s Parsortix® system is FDA cleared for its intended use in metastatic breast cancer and is currently the first and only FDA cleared medical device to harvest intact circulating cancer cells from blood.

The Parsortix system enables a liquid biopsy (a simple blood test) to be used to provide the circulating metastatic breast cancer cells to the user in a format suitable for multiple types of downstream analyses.  The system is based on a microfluidic device that captures cells based on a combination of their size and compressibility.  The system is epitope independent and can capture all phenotypes of CTCs (epithelial, mesenchymal and EMTing CTCs) as well as CTC clusters in a viable form (alive).  CTCs harvested from the system enable a complete picture of a cancer to be seen; as being an intact cell they allow DNA, RNA and protein analysis as well as cytological and morphological examination and may provide comparable analysis to a tissue biopsy in metastatic breast cancer. Because CTC analysis is a non-invasive process, unlike tissue biopsy, it can be repeated as often as needed. This is important because cancer develops and changes over time and there is a clear medical need for up-to-date information on the status of a patient’s tumor. In addition, the live CTCs harvested by the Parsortix system can be cultured, which offers the potential for testing tumor response to drugs outside the patient.

Join our Team:

This is an exciting time at ANGLE and our research and development team in Guildford are looking for a Group Leader specialising in Molecular Biology.

You will be an experienced scientist who can apply your expertise of molecular activities such as qPCR and NGS, and act as a resident expert of molecular biology within our team.

This important position will be responsible for managing a core functional group within our company, with the overarching goal of product development.

At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading edge translational research into clinical diagnostics. We offer the potential for significant corporate growth and career development. We promote a culture of collaboration and shared excellence while encouraging an open and honest exchange of ideas.

We are always in search of potential employees who share our vision and want to make a difference today. In your submission, please describe your background and what you can bring to our team along with attaching your resume.

Principal Accountabilities:

  • Key responsibilities include identifying, resolving and escalating resource issues, as well as resolving technical, and operational problems by proactively identifying and managing potential risks to allocated projects
  • Work across the organisation and with other Group Leaders and Head of R&D to ensure the success of projects and company goals
  • Manage projects (in a matrix structure) that require considerable innovation resulting in a major impact on company performance, setting goals and determining route(s) to delivery.  This job requires the job holder to be a flexible independent problem solver and able to make recommendations on proposed routes forward in our complex and fast-paced environment
  • Take a pro-active approach to managing own time and the group’s time and priorities, as well as providing daily guidance to the team on work packages and corporate/project priorities
  • Provide scientific expertise and advice to other members of the company
  • Provide detailed, comprehensive plans and specifications for projects
  • Identify, document and manage dependencies and risks for projects
  • Manage procedures and metrics to monitor quality and mitigate risk and to ensure deadlines and budgets are met
  • Manage key technical and analytical studies relating to circulating tumour cell biology
  • Develop molecular assays (for example: qPCR, digital droplet PCR, NGS)
  • Represent the company to customers and manage relationships with external organisations and collaborators as required
  • Work within the New Product Development process and provide documentation and supporting evidence to ISO13485 and 21cfr820 standard for gate reviews

Qualifications, Experience, Knowledge and Attributes:

  • PhD in Life Sciences, with post-doctoral experience or equivalent in oncology and molecular biology, ideally gained in the in vitro diagnostics or assay development/validation
  • Experience in industry is essential
  • Experience in project management is essential
  • Experience in a range of molecular biology techniques (including (dd)PCR and NGS) is essential
  • Molecular-based assay development experience is essential
  • Must have experience working in a regulated environment – medical device or therapeutics.  Experience with Medical Device regulations and standards including, but not limited to, 21 CFR 820, ISO 13485, 93/42/EEC, IVD 98/79 EC, ISO14971, GMP, GLP and QSR a definite plus
  • An eye for detail and a commitment to high quality data
  • Strong team player with excellent oral and written communication skills
  • Possess a flexible, can-do approach to the requirements of the job

As a member of our highly skilled and fast-growing team you will receive opportunities for development and a competitive benefits package.

Please let us know if you require disability-related accommodation during the recruitment process so that we can work with you to meet your needs.

Furthermore, please be advised that if you submit an application to us for this position, your application and personal details will be processed in accordance with our Data Privacy Notice for Job Candidates.

Important notice to Employment Businesses/ Agencies:

ANGLE does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact our ANGLE recruitment team to obtain prior written authorisation before referring any candidates. In the absence of such written authorisation being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of ANGLE. ANGLE shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

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