ANGLE is a world-leading liquid biopsy company with offices in Guildford (UK), Toronto (Canada) and Greater Philadelphia area (USA). ANGLE’s patented liquid biopsy platform and associated assays have the potential to be used throughout the cancer care pathway to provide clinicians with individualised, up-to-date, and clinically actionable insight into every patient’s cancer. This could enable patients to receive timely, personalised treatment and improve clinical outcomes.

Liquid biopsies involve sampling and analysis of peripheral blood to identify signs of cancer. Liquid biopsy is minimally invasive and can be undertaken safely in community clinics to provide patients with a rapid diagnosis and timely treatment with targeted therapies. Liquid biopsy may also help to safely monitor cancer patients in remission to provide early warning of recurrence.

In 2021 ANGLE opened GCLP compliant clinical laboratories in Guildford (UK) and in the Greater Philadelphia area (USA) to provide “pharma services” for cancer drug trials and, once the labs are accredited, laboratory developed tests (LDTs) for patient management. We are also pursuing an FDA product clearance for the Parsortix^® system and have submitted a full De Novo submission, which is currently in substantive review with the FDA.

Join our Team:

This is an exciting time at ANGLE and our research and development facilities in Guildford are looking for a Group Leader specialising in Molecular Biology.

You will be an experienced scientist who can apply your expertise of molecular activities such as qPCR and NGS, and act as a resident expert of molecular biology within our team.

This important position, will be responsible for managing a core functional group within our company, with the overarching goal of product development.

At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading edge translational research into clinical diagnostics. We offer the potential for significant corporate growth and career development. We promote a culture of collaboration and shared excellence while encouraging an open and honest exchange of ideas.

We are always in search of potential employees who share our vision and want to make a difference today. In your submission, please describe your background and what you can bring to our team along with attaching your resume

Principal Accountabilities:

• Key responsibilities include identifying, resolving and escalating resource issues, as well as resolving technical, and operational problems by proactively identifying and managing potential risks to allocated projects
• Work across the organisation and with other Group Leaders and Head of R&D to ensure the success of projects and company goals
• Manage projects (in a matrix structure) that require considerable innovation resulting in a major impact on company performance, setting goals and determining route(s) to delivery. This job requires the job holder to be a flexible independent problem solver and able to make recommendations on proposed routes forward in our complex and fast-paced environment
• Take a pro-active approach to managing own time and the group’s time and priorities, as well as providing daily guidance to the team on work packages and corporate/project priorities
• Provide scientific expertise and advice to other members of the company
• Provide detailed, comprehensive plans and specifications for projects
• Identify, document and manage dependencies and risks for projects
• Manage procedures and metrics to monitor quality and mitigate risk and to ensure deadlines and budgets are met
• Manage key technical and analytical studies relating to circulating tumour cell biology
• Develop molecular assays (for example: qPCR, digital droplet PCR, NGS)
• Represent the company to customers and manage relationships with external organisations and collaborators as required
• Work within the New Product Development process and provide documentation and supporting evidence to ISO13485 and 21cfr820 standard for gate reviews

Qualifications, Experience, Knowledge and Attributes:

• PhD in Life Sciences, with post-doctoral experience or equivalent in oncology and molecular biology, ideally gained in the in vitro diagnostics or assay development/validation
• Experience in industry is essential
• Experience in project management is essential
• Experience in a range of molecular biology techniques (including (dd)PCR and NGS) is essential
• Molecular-based assay development experience is essential
• Must have experience working in a regulated environment – medical device or therapeutics. Experience with Medical Device regulations and standards including, but not limited to, 21 CFR 820, ISO 13485, 93/42/EEC, IVD 98/79 EC, ISO14971, GMP, GLP and QSR a definite plus
• An eye for detail and a commitment to high quality data
• Strong team player with excellent oral and written communication skills
• Possess a flexible, can-do approach to the requirements of the job

As a member of our highly skilled and fast-growing team you will receive opportunities for development and a competitive benefits package.

Salary estimate – from £47,700 per annum

Please let us know if you require disability-related accommodation during the recruitment process so that we can work with you to meet your needs.

Furthermore, please be advised that if you submit an application to us for this position, your application and personal details will be processed in accordance with our Data Privacy Notice for Job Candidates.

Important notice to Employment Businesses/ Agencies

ANGLE does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact our ANGLE recruitment team to obtain prior written authorisation before referring any candidates. In the absence of such written authorisation being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of ANGLE. ANGLE shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.