Group Leader (Molecular Biology)

ANGLE is a world-leading liquid biopsy company with offices in Guildford (UK), Toronto (Canada) and Philadelphia (US).

ANGLE’s proven patent protected liquid biopsy platform products have the potential to be used in cancer diagnostics to enable early, accurate identification of an individual’s condition for the prevention, treatment, and monitoring of disease.

Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020*. ANGLE’s liquid biopsy technologies have the potential to help clinicians select the most appropriate drugs and therapies for an individual patient. As such, our technologies support the development of Precision Medicine.

In 2021 we opened GCLP compliant clinical laboratories in Guildford (UK) and Philadelphia (USA) to provide “pharma services” for cancer drug trials and, once the labs are accredited, laboratory developed tests (LDTs) for patient management. The pharma services business offers dynamic analysis of patient condition before, during and after the patient receives the drug, assessing both CTCs and CTC clusters recovered from a simple blood test. We are also pursuing an FDA product clearance for the Parsortix system and have submitted a full De Novo submission, which is currently in substantive review with FDA.

*IARC, WHO Cancer (who.int)

This is an exciting time at ANGLE and our research and development facilities in Guildford, UK are looking for a Group Leader specialising in Molecular Biology.

This is an important position, and the postholder will be responsible for managing a core functional group within the company, with the overarching goal of product development. Key responsibilities include identifying, resolving and escalating resource issues, as well as resolving technical, and operational problems by proactively identifying and managing potential risks to allocated projects

Principal Accountabilities:

• Works across the organisation and with other Group Leaders and Head of R&D to ensure the success of projects and company goals.
• Manages projects that require considerable innovation resulting in a major impact on company performance, setting goals and determining route(s) to delivery. This job requires the job holder to be a flexible independent problem solver and able to make recommendations on proposed routes forward in our complex and fast-paced environment.
• Takes a pro-active approach to managing their own and their group’s time and priorities, as well as providing daily guidance to their team on work packages and corporate/project priorities.
• Act as a resident expert of molecular biology within the organisation.
• Provide scientific expertise and advice to other members of the company.
• Manage projects in a matrix structure across multidisciplinary teams (molecular biology, cell biology and imaging, engineering, software, regulatory/clinical and quality).
• Manage a functional/technical team(s) by influence and displayed leadership skills, in line with the ANGLE Management Charter.
• Manage key technical and analytical studies relating to circulating tumour cell biology.
• Develop molecular assays (for example: qPCR, digital droplet PCR, NGS).
• Have close interactions with the entire R&D team and wider company. Work with other group leaders to forecast staffing requirements, share and allocate resources within the team.
• Manage relationships with external organisations and collaborators as required.
• Communicate program/project status and plans to management.
• Work within the New Product Development process and provide documentation and supporting evidence to ISO13485 and 21cfr820 standard for gate reviews.
• Represent the company to customers and at external scientific meetings as required.
• Foster quality of data within the organisation.
• Write/review external scientific publications and Application Notes.
• As required, work with marketing and/or business development to understand and document customer/product requirements.
• Provide technical support as required to support commercial partnerships and customers.
• Contribute to laboratory record management and quality systems.
• Undertake additional adhoc / project work as required.

Qualifications, Experience, Knowledge and Attributes:

• A PhD in Life Sciences, with post-doctoral experience or equivalent in oncology and molecular biology, ideally gained in the in vitro diagnostics or assay development/validation.
• Experience in industry is essential.
• Experience in managing people working in a multi-disciplinary project team, including management of contract R&D, preferably in a matrix-based organisation.
• Experience in project management is essential (including but not limited to development of project timelines, budgets and deliverables).
• Experience in a range of molecular biology techniques (including (dd)PCR and NGS).
• Molecular-based assay development experience is essential.
• Must have experience working in a regulated environment – medical device or therapeutics. Experience with Medical Device regulations and standards including, but not limited to, 21 CFR 820, ISO 13485, 93/42/EEC, IVD 98/79 EC, ISO14971, GMP, GLP and QSR a definite plus.
• Experience with visual tools for project tracking, management and reporting.
• An ability to problem-solve over a complex range of tasks subject to competing contractual, financial, personnel and time constraints.
• Organisational skills and the ability to rapidly prioritise tasks in response to unexpected opportunities or risks.
• Ability to manage and coordinate the timely creation and delivery of project reports.
• Able to provide scientific mentoring and training to develop others and promote good scientific practice. Demonstrated ability to manage teams from the front and through influencing skills.
• Ability to plan staffing levels and assignments across a portfolio of projects.

Join our Team

At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading edge translational research into clinical diagnostics. We offer the potential for significant corporate growth and career development. We promote a culture of collaboration and shared excellence while encouraging an open and honest exchange of ideas.

We are always in search of potential employees who share our vision and want to make a difference today. In your submission, please note the position you are interested in, describe your background and what you can bring to our team along with attaching your resume.

As a member of our excellent and fast-growing team you will receive opportunities for development and a competitive benefits package.

Salary estimate – £negotiable

Please let us know if you require disability-related accommodation during the recruitment process so that we can work with you to meet your needs.

Important notice to Employment Businesses/ Agencies
ANGLE does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact our ANGLE recruitment team to obtain prior written authorisation before referring any candidates. In the absence of such written authorisation being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of ANGLE. ANGLE shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.