Scientist II

Guildford, UK

ANGLE is a world-leading liquid biopsy company with offices in Guildford (UK), Toronto (Canada) and  Philadelphia (US). ANGLE’s proven patent protected liquid biopsy platform products have the potential  to be used in cancer diagnostics to enable early, accurate identification of an individual’s condition for  the prevention, treatment, and monitoring of disease.

With 1 in 2 UK people being diagnosed with cancer in their lifetime*, ANGLE’s liquid biopsy  technologies have the potential to help clinicians select the most appropriate drugs and therapies for  an individual patient. As such, our technologies support the development of Precision Medicine.

In 2021 we opened GCLP compliant clinical laboratories in Guildford (UK) and Philadelphia (USA) to provide “pharma services” for cancer drug trials and, once the labs are accredited, laboratory  developed tests (LDTs) for patient management. The pharma services business offers dynamic analysis  of patient condition before, during and after the patient receives the drug, assessing both CTCs and  CTC clusters recovered from a simple blood test. We are also pursuing an FDA product clearance  for the Parsortix system and have submitted a full De Novo submission, which is currently in  substantive review with FDA.

*Source: Cancer – NHS ( 

This is an exciting time at ANGLE and our research and development facilities in Guildford, UK are  looking for a Scientist specialising in methods development and validation in support of clinical  diagnostic products.

An important aspect of this position is support of other projects/programs within the Company and  the establishment of company-wide methods and SOP’s relative to Cell Biology and Imaging. The job  holder undertakes work that requires considerable innovation resulting in a major impact on company  performance. The job is laboratory-based as well as office-based working in a multi-disciplinary team  responsible for aspects of the development and validation of ANGLE’s clinical diagnostic products.  Goals and routes are agreed with supervisor, but an ability to think ahead in a complex environment  to solve problems and make recommendations on proposed routes to the Group Leader is expected.

Principal Accountabilities:

  • Hands-on laboratory work, primarily in the area of Cell Biology and Imaging.
  • Responsible for on-time and on-budget delivery of work packages within a project.
  • Act as Project leader on one project as required.
  • Responsible to ensuring quality and regulatory compliance of projects.
  • Timely reporting of progress on projects and on metrics to monitor and mitigate risk and to  ensure product deadlines are met.
  • Manage the day to day running of assigned development projects within the Quality Management  System (ISO13485) and working to the New Product Development (NPD) operating  procedure.
  • Provide scientific and technical support to programmes and projects.
  • Provide scientific expertise, advice and practical support to senior management in all technical  areas of the company.
  • Independently keep a current knowledge base in areas of scientific and technical research,  making recommendations on new processes, technologies and product opportunities.
  • Undertake additional adhoc / project work as required.

Qualifications, Experience, Knowledge and Attributes:

  • PhD in Life Sciences, or MSc with experience or equivalent in oncology, cell biology or imaging,  preferably gained in the in vitro diagnostics industry in diagnostic assay development/validation.
  • Demonstrated expertise and hand-on competency in cell biology and imaging technologies.
  • Experience working to strict quality standards such as Medical Device regulations and standards  including, but not limited to, 21 CFR 820, ISO 13485, 93/42/EEC, IVD 98/79 EC, ISO14971,  GMP, GLP, QSR.
  • Experimental design and project/resource planning skills.
  • Ability to manage and coordinate the timely creation and delivery of project reports.
  • Manage and deliver product development projects to agreed performance specifications, on  time and within budget.
  • Effective time management and an ability to delegate work to team members and manage  delivery.
  • Strong team player with excellent communication skills.
  • Commercially astute and a dynamic, strategic thinker.
  • Possess a flexible, can-do approach to the requirements of the job
  • Excellent oral and written communication skills.
  • Organisational skills and the ability to rapidly prioritise tasks in response to unexpected  opportunities or risks.
  • Strong verbal and written communication skills.
  • Ability to multitask and prioritise to meet deadlines.
  • Ability to work both independently with minimal supervision as well as in a team environment.
  • An eye for detail and commitment to high quality data.
  • Continuous learner with a keen appetite for cross-disciplinary work.
  • A flexible, can-do approach to the requirements of the job.
  • Entrepreneurial thinking and work ethic.

The following skills and experience would be an advantage:

  • Experience in statistical analysis methods.
  • Experience in a clinical laboratory environment, particularly, oncology.
  • Knowledge / experience in transferring a laboratory process to automated instrumentation.

Due to the nature of the role, our requirement is for this position to be Guildford based, with flexibility to work shift patterns if required.

Join our Team

At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading edge translational  research into clinical diagnostics. We offer the potential for significant corporate growth and career  development. We promote a culture of collaboration and shared excellence while encouraging an open  and honest exchange of ideas.

We are always in search of potential employees who share our vision and want to make a difference  today. In your submission, please note the position you are interested in, describe your background  and what you can bring to our team along with attaching your resume.

As a member of our excellent and fast-growing team you will receive opportunities for development  and a competitive benefits package.

Salary estimate – £Competitive 

Please let us know if you require disability-related accommodation during the recruitment process so  that we can work with you to meet your needs.

If you submit an application to us, your application and personal details will be processed in accordance  with our Data Privacy Notice for Job Candidates.

Important notice to Employment Businesses/ Agencies
ANGLE does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact our ANGLE recruitment team to obtain prior written authorisation before referring any candidates. In the absence of such written authorisation being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of ANGLE. ANGLE shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.



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