Senior Scientist (CBI – Assay Development)

Guildford, UK

ANGLE is a world-leading liquid biopsy company with offices in Guildford (UK), Toronto (Canada) and Philadelphia (US). ANGLE’s proven patent protected liquid biopsy platform products have the potential to be used in cancer diagnostics to enable early, accurate identification of an individual’s condition for the prevention, treatment, and monitoring of disease.

Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020*. ANGLE’s liquid biopsy technologies have the potential to help clinicians select the most appropriate drugs and therapies for an individual patient. As such, our technologies support the development of Precision Medicine.

In 2021 we opened GCLP compliant clinical laboratories in Guildford (UK) and Philadelphia (USA) to provide “pharma services” for cancer drug trials and, once the labs are accredited, laboratory developed tests (LDTs) for patient management. The pharma services business offers dynamic analysis of patient condition before, during and after the patient receives the drug, assessing both CTCs and CTC clusters recovered from a simple blood test. We are also pursuing an FDA product clearance for the Parsortix system and have submitted a full De Novo submission, which is currently in substantive review with FDA.

*IARC, WHO Cancer (

This is an exciting time at ANGLE and our research and development facilities in Guildford, UK are looking for a Senior Scientist specialising in CBI – Assay Development.

This important position, primarily responsible for methods development and validation in support of novel clinical assays in biological samples for pharma services clients and to support other projects/programs within the company and to establish company-wide methods and SOP’s relative to Cell Biology and Imaging.

The job holder undertakes work that requires considerable innovation resulting in a major impact on company performance.

Principal Accountabilities:

  • Hands-on laboratory work preliminary in the area of Cell Biology and Imaging
  • Assist the Group Leader in the management of the group
  • Act as Project Leader on one or more projects as required
  • Responsible for on-time and on-budget delivery of project milestones
  • Responsible to ensuring quality and regulatory compliance of projects
  • Manage the day to day running of assigned development projects within the Quality Management System (ISO13485) and working to the New Product Development (NPD) operating procedure
  • Remain abreast of scientific and technical advances, especially in your field of expertise, making recommendations on new processes, technologies and product opportunities
  • Provide scientific and technical support to programmes and projects
  • Other duties as assigned/ undertake additional adhoc / project work as required.

Qualifications, Experience, Knowledge and Attributes:

  • PhD in Life Sciences, with post-doctoral experience in oncology, molecular biology or cell biology or equivalent, preferably gained in the in vitro diagnostics industry in diagnostic assay development/validation
  • Demonstrated expertise and hand-on competency in cell biology and imaging technologies
  • Experience managing people working in multi-disciplinary project teams, including management of contract R&D
  • Experience working to strict quality standards such as Medical Device regulations and standards including, but not limited to, 21 CFR 820, ISO 13485, 93/42/EEC, IVD 98/79 EC, ISO14971, GMP, GLP, QSR
  • Demonstrated ability to manage teams by influence and displayed leadership skills
  • Organisational skills and the ability to rapidly prioritise tasks in response to unexpected opportunities or risks
  • Ability to manage and coordinate the timely creation and delivery of project reports
  • Effective time management and an ability to delegate work to team members and manage delivery
  • Capability to contribute to original research and to synthesise research findings into proposals for a variety of commercial and technical audiences
  • Experimental design and project/resource planning skills
  • Manage and deliver complex product development projects to agreed performance specifications, on time and within budget
  • Strong team player with excellent oral and written communication skills
  • Possess a flexible, can-do approach to the requirements of the job
  • Knowledge / experience in transferring a laboratory process to automated instrumentation
  • Ability to problem-solve over a complex range of tasks subject to competing contractual, financial, personnel and time constraints.
  • Organisational skills and the ability to rapidly prioritise tasks in response to unexpected opportunities or risks.
  • Ability to manage and coordinate the timely creation and delivery of project reports. Ability to multitask and prioritize to meet deadlines.
  • Able to provide scientific mentoring and training to develop others and promote good scientific practice. Demonstrated ability to manage teams from the front and through influencing skills.
  • Ability to plan staffing levels and assignments across a portfolio of projects
  • Due to nature of role, the requirement is for Guildford based, office hours and 5 days per week

Join our Team

At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading edge translational research into clinical diagnostics. We offer the potential for significant corporate growth and career development. We promote a culture of collaboration and shared excellence while encouraging an open and honest exchange of ideas.

We are always in search of potential employees who share our vision and want to make a difference today. In your submission, please note the position you are interested in, describe your background and what you can bring to our team along with attaching your resume.

As a member of our excellent and fast-growing team you will receive opportunities for development and a competitive benefits package.

Salary estimate – £37000 – £39000

Please let us know if you require disability-related accommodation during the recruitment process so that we can work with you to meet your needs.

Important notice to Employment Businesses/ Agencies
ANGLE does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact our ANGLE recruitment team to obtain prior written authorisation before referring any candidates. In the absence of such written authorisation being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of ANGLE. ANGLE shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.



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