Senior Scientist (Engineering)

Guildford, UK

About ANGLE:

ANGLE is a world-leading liquid biopsy company with offices in Guildford (UK), Toronto (Canada) and Greater Philadelphia area (USA). ANGLE’s patented liquid biopsy platform and associated assays have the potential to be used throughout the cancer care pathway to provide clinicians with individualised, up-to-date, and clinically actionable insight into every patient’s cancer. This could enable patients to receive timely, personalised treatment and improve clinical outcomes.

Liquid biopsies involve sampling and analysis of peripheral blood to identify signs of cancer. Liquid biopsy is minimally invasive and can be undertaken safely in community clinics to provide patients with a rapid diagnosis and timely treatment with targeted therapies. Liquid biopsy may also help to safely monitor cancer patients in remission to provide early warning of recurrence.

In 2021 ANGLE opened GCLP compliant clinical laboratories in Guildford (UK) and in the Greater Philadelphia area (USA) to provide “pharma services” for cancer drug trials and, once the labs are accredited, laboratory developed tests (LDTs) for patient management.

In May 2022, ANGLE achieved FDA clearance for a novel medical device for the capture and harvest of circulating tumour cells (CTCs) from metastatic breast cancer patient blood for subsequent analysis.

Join our Team:

This is an exciting time at ANGLE and our Product and Technology Development (PTD) team in Guildford are looking for a Senior Scientist who will be primarily responsible for methods development and validation in support of clinical diagnostic products.​

An important aspect of this position is support of projects/programs within the company and the establishment of company-wide methods and SOP’s relative to medical device development. The job holder will undertake work that requires considerable innovation resulting in a major impact on company performance.  Goals are apparent, but route(s) are undetermined, so the job holder must be flexible and able to think ahead in a complex environment to solve problems and make recommendations on proposed routes.

At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading edge translational research into clinical diagnostics. We offer the potential for significant corporate growth and career development. We promote a culture of collaboration and shared excellence while encouraging an open and honest exchange of ideas.

We are always in search of potential employees who share our vision and want to make a difference today. In your submission, please describe your background and what you can bring to our team along with attaching your resume.

Principal Accountabilities:

  • Hands-on laboratory work, primarily in the area of medical device development:

    • perform experimental design and undertake performance evaluation of the company’s circulating cell isolation products
    • build and test prototype designs
    • develop and test approaches for the assessment of product functionality; specifically investigating factors that affect performance and reliability
  • Assist the Group Leader in the management of the group
  • Act as Project leader on one or more projects as required
  • Responsible for on-time and on-budget delivery of project milestones
  • Responsible to ensuring quality and regulatory compliance of projects
  • Manage the day to day running of assigned development projects within the Quality Management System (ISO13485) and working to the New Product Development (NPD) operating procedure
  • Remain abreast of scientific and technical advances, especially in your field of expertise, making recommendations on new processes, technologies and product opportunities
  • Provide scientific and technical support to programmes and projects
  • Provide scientific and engineering expertise, advice and practical support to senior management in all technical areas of the company, as required
  • With group leaders forecast staffing requirements
  • Other duties as assigned
  • Undertake additional adhoc / project work as required

Qualifications, Experience, Knowledge and Attributes:

  • PhD or equivalent experience in Life Sciences or Engineering related to Product Development (e.g. mechanical engineer or fluidics engineer), with at least 2 years post-doctoral experience in oncology, cell biology or medical device development, preferably gained in the in vitro diagnostics industry in diagnostic product development/validation
  • Demonstrated expertise and hand-on competency in product development, preferably related to medical devices
  • Experience managing people working in multi-disciplinary project teams, including management of contract R&D
  • Experience working to strict quality standards such as Medical Device regulations and standards including, but not limited to, 21 CFR 820, ISO 13485, 93/42/EEC, IVD 98/79 EC, ISO14971, GMP, GLP, QSR
  • Demonstrated ability to manage teams by influence and displayed leadership skills
  • Ability to manage and coordinate the timely creation and delivery of project reports
  • Effective time management and an ability to delegate work to team members and manage delivery
  • Capability to contribute to original research and to synthesise research findings into proposals for a variety of commercial and technical audiences
  • Experimental design and project/resource planning skills
  • Manage and deliver complex product development projects to agreed performance specifications, on time and within budget
  • Organisational skills and the ability to rapidly prioritise tasks in response to unexpected opportunities or risks
  • Excellent accuracy and attention to detail in practical and written work
  • Strong team player with excellent analytical and interpersonal skills
  • Good report writing skills, with the ability to communicate results to technical and non-technical staff
  • Ability to work independently with minimal supervision
  • Continuous learner with a keen appetite for cross-disciplinary work
  • A flexible, can-do approach to the requirements of the job
  • Entrepreneurial thinking and work ethic

As a member of our highly skilled and fast-growing team you will receive opportunities for development and a competitive benefits package.

Please let us know if you require disability-related accommodation during the recruitment process so that we can work with you to meet your needs.

Furthermore, please be advised that if you submit an application to us for this position, your application and personal details will be processed in accordance with our Data Privacy Notice for Job Candidates.

Important notice to Employment Businesses/ Agencies:

ANGLE does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact our ANGLE recruitment team to obtain prior written authorisation before referring any candidates. In the absence of such written authorisation being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of ANGLE. ANGLE shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.


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