Andrew Newland is Chief Executive of ANGLE plc. He has an MA in Engineering Science from the University of Cambridge and is a qualified Chartered Accountant. He has 18 years of medical diagnostics experience and has specialised in the liquid biopsy space for the last nine years.
Andrew founded ANGLE in 1994. In 1999, Andrew led the team that founded the medical diagnostic company, Acolyte Biomedica. Acolyte was the first ever spin-out of the Defence Science and Technology Laboratory (Dstl) Porton Down, which specialised in rapid diagnosis of MRSA the ‘hospital super-bug’. Andrew chaired the company for several years and successfully led the company through three major rounds of venture capital investment. Andrew also founded Provexis, the first ever spin-out of Rowett Institute, Europe’s leading nutrition research institute. Andrew chaired the Board of Provexis, a specialist nutraceutical company with a heart-health product, through to its successful flotation in 2005.
Todd E. Druley, M.D., Ph.D.
Chief Medical Officer
Todd Druley, MD, PhD is the Chief Medical Officer for ANGLE plc. He earned his MD and PhD in Molecular Genetics from the University of Illinois and then studied pediatric oncology at St. Louis Children’s Hospital / Washington University School of Medicine in St. Louis, Missouri USA.
Also in 2019, Dr. Druley joined the molecular diagnostic company, ArcherDX, as their first Chief Medical Officer, establishing the medical and translational program for the company. In this wide-ranging role, his teams for translational research, medical liaisons and medical writing participated in activities including regulatory filings, pharmaceutical clinical trials and companion diagnostic development, key opinion leader outreach and collaboration, product development and validation as well as supporting sales, marketing and company publications. ArcherDX was acquired by Invitae Corporation in 2020 where Dr. Druley served as a leader in translational and commercial applications in somatic oncology genetics until 2021. At ANGLE, he seeks to guide development and application of the company’s unique circulating tumour cell enrichment technology to better provide clinicians with actionable information in order to improve cancer patient outcomes.
Chief Commercial Officer
Paul Smith is Chief Commercial Officer at ANGLE. Prior to joining ANGLE, Paul most recently served as President and CEO of Axela Inc. a company specializing in the development of multiplex biomarker tools. He has more than 30 years of experience in the life science instrumentation field with a diverse background in sales, marketing and field operations.
Chief Financial Officer
Ian Griffiths is the Finance Director of ANGLE plc. He has specialised in technology commercialisation for over 30 years and is an expert on the development and growth of new technology-based businesses. Ian has a BSc in Mathematics with Management Applications from Brunel University and is qualified as a chartered accountant. For seven years he worked for KPMG, initially in accountancy with a special work focus, then in management consulting within KPMG's High Technology Consulting Group where he specialised in financial modelling, business planning, corporate finance, market development and strategy work.
Head of R&D
Anne-Sophie Pailhes-Jimenez is the Head of R&D at ANGLE Europe. She joined ANGLE in 2016 and is responsible for all R&D laboratory activities and projects. She has over 13 years of experience in cell biology and cancer research in the biotech and biopharma space.
An expert in cellular biology and immunofluorescence technology, Anne-Sophie has been managing multiple projects to develop downstream assays including immunofluorescence staining, and leading R&D activities on further characterization of CTCs. Previously, she worked as senior scientist for 6 years at the Gustave Roussy Institute in Paris, France where she gained a wealth of experience in cellular biology in the oncology area. Before joining ANGLE, Anne-Sophie managed the biology team at a biopharmaceutical company that focused on the development of innovative immunotherapy solutions for cancer treatment. Anne-Sophie has an MSc in biotechnological engineering specialising in molecular biology from the Institut National des Sciences Appliquées de Toulouse (INSA Toulouse).
Head of Clinical Laboratories
Madeline Repollet joined ANGLE in 2020 as the Head of Clinical Laboratories. Dr. Repollet holds a PhD in Health Care Administration, a MS in Quality Assurance & Regulatory Affairs and a BS in Biology. She is Board Certified as a Cytotechnologist by the American Society for Clinical Pathology.
Madeline started her career working as a Cytotechnologist and managing Pathology Laboratories in Puerto Rico and Minnesota. In 1999, she joined Immunicon, where she worked for R&D, Engineering and Clinical Development. Madeline is co-developer of the CellSearch® CTC definition, establishing the first CellSearch® training program and managing laboratory logistics for the clinical studies that obtained De Novo clearance for CellSearch®.
Madeline has more than 30 years of clinical lab experience, 21 of those in the liquid biopsy space. Madeline has years of global laboratory management experience, working with clinical laboratories in the US, The Netherlands, Belgium and Italy. During that time, Madeline established clinical laboratory quality management systems compliant with CLIA and ISO 15189 and obtained licenses from the States of Pennsylvania, California, New York, Florida, Rhode Island and Maryland.
Madeline is co-author in several circulating tumor cells publications and holds two patents in those technologies.
Business Development Director
Michael has extensive experience of commercialising new technologies, with a solid background in strategic and operational leadership. Michael joined ANGLE in 2009 to lead a government backed technology incubator. The incubator evaluated more than 60 early stage technology companies from around the UK before selecting the highest potential start-ups and providing intense consultancy support in setting technology milestones, developing an effective business model, building collaborations and securing early customers.
Director of Manufacturing & Regulatory Affairs
Martin is the Head of Manufacturing and Regulatory at ANGLE plc, a Chartered Engineer and holds an MEng degree in Electrical and Electronic Engineering from The University of Nottingham. He joined ANGLE in 2004 and first specialised in technology commercialisation and knowledge transfer projects supporting businesses, particularly involving universities and other specialist knowledge and research centres.
Clinical Studies Director
Craig Miller joined ANGLE in March of 2016 as the Clinical Studies Director, where he is responsible for driving the clinical development activities of ANGLE. He has over 20 years of experience in the RUO and IVD diagnostics industry, including clinical trial management, clinical data management, biostatistics, regulatory submissions, and manuscript writing and editing (Craig is a co-author on over 80 peer-reviewed publications in the field of oncology and diagnostics).
Vice President Commercial Operations
Nick Claxton is VP Commercial Operations for ANGLE plc, and is responsible for forging corporate relationships and developing global distribution networks to commercialise ANGLE’s products and services.
Nick joined Becton Dickinson where he held the position of Business Director responsible for sales, marketing, client and technical services for 10 years. From there he moved to Roche as head of marketing, following the acquisition of Boehringer Mannheim. In 2000 Nick joined LGC (formerly Laboratory of the Government Chemist) as Director of Forensics, responsible for the 7 geographical laboratory sites along with the sales and marketing for the group. The role required direct relationships with the UK Government Home Office and the 43 constabularies of the UK and Northern Ireland.
In 2007 Nick joined the UK Board of Olympus Scientific as Scientific Director with responsibilities for the Clinical Chemistry and Microscopy divisions. In 2010 Nick became Business Director for a start-up company called Epistem, where they launched the first hand held PCR device (Genedrive) developed for field based TB testing along with other infectious diseases.
In 2015 Nick joined another start up, Premaitha Health as Chief Commercial Officer. Premaitha were the first company to achieve a CE/IVD for non invasive pre natal testing using next generation sequencing platforms.
Nick is also a non-executive director of two companies, MEMP ( Middle East Medical Portal) which helps small British medical companies enter the Middle East and Inception Associates which mentors early start ups through business planning and raising investment.
Associate Commercial Director
Ghada Abuali is an Associate Commercial Director at ANGLE plc and responsible for various corporate and commercial activities. Dr Abuali has a PhD in cancer research from Imperial College London, an MBA from Imperial Business School, and an MSc in Molecular Diagnostics from University of Nottingham. She has over 15 years of scientific and commercial experience in the molecular diagnostic industry.
Ghada started her career working as a medical laboratory scientist where she established and managed a CAP-certified molecular diagnostics laboratory. She then pursued a PhD with a focus on cancer gene therapy and the role of a novel cancer-specific apoptosis inducing gene specifically in renal cancer. After her PhD, she completed a postdoctoral fellowship at the Cleveland Clinic focusing on prostate cancer where she developed an ultra-sensitive, real-time PCR assay for the detection of a low frequency/rare allele mutation that significantly correlates with the progression of castration resistant prostate cancer. Her MSc, PhD, and postdoctoral research projects were all published in peer-reviewed journals with the latter published in Lancet Oncology and replicated by independent groups.
Prior to joining ANGLE, she led a successful career in various technical and commercial roles, most recently as Senior Manager at QIAGEN for OEM sales in EMEA where she managed B2B commercial relationships, consistently overachieving multimillion-dollar sales targets. Since joining ANGLE as Associate Commercial Director in March 2020, she has been driving a variety of commercial and business activities whilst providing executive support.
Senior Group Leader – Product and Technology Development
Stefan Peter leads the Product and Technology team. He joined ANGLE in 2014 and is responsible for the device development with doctoral and post-doctoral experience in biology and engineering. Dr Peter holds a PhD in cell biology and proteomics from Sheffield University and a diploma degree in biotechnology.
Dr Stefan Peter gained a diploma degree in biotechnology (Dipl. Ing. Biotechnology) from the University of Applied Sciences Weihenstephan (Freising, Germany), followed by a PhD from Sheffield University (UK) where he developed expertise in cell biology and proteomics. During his PhD he investigated large scale expansion of mesenchymal stem cells for subsequent proteomic characterization. He developed a method to expand primary mesenchymal stem cells in suspension rather than on a substrate and gained insight into proteomic changes in these cell cultures.
His post-doctoral research (also at Sheffield University) focused on epigenetic changes in bladder cancer. Using a commercially available microarray technology, he investigated the expression of microRNAs and long-non-coding RNAs in different stages of bladder cancer and identified a panel of potential new biomarkers, whose biological function was investigated in cancer cells lines via different genetic knock-down assays. He subsequently joined ANGLE in 2014 as Senior Scientist and helped to set up a biological laboratory to drive the development of the Parsortix technology.
As Senior Group Leader for Product and Technology Development, Stefan is now leading a team at ANGLE that drives the research and development of the Parsortix cell separation technology with a focus on device development, including both the Parsortix instrument and the Parsortix separation cassette. With expertise in biology and engineering he interlinks device development and biological assay development to ensure successful delivery of projects within ANGLE’s New Product Development (NPD) process.