Laboratory services

Liquid biopsy solutions for biopharmaceutical & translational research

ANGLE’s clinical laboratory provides specialized circulating tumor cell (CTC) enrichment and analysis services

Our mission is to advance the development of new cancer therapies and personalized medicine

We use Parsortix technology to harvest CTCs and CTCs clusters for subsequent DNA, RNA and protein expression analysis

Our team will work with you to ensure your success through all phases of your clinical trials

Currently offering the following standardized analyses:

  • Enumeration of epithelial, mesenchymal and epithelial-to-mesenchymal transitioning (EMT) CTCs and CTC clusters
  • DNA Damage Response (DDR) proteins
  • PD-L1 protein expression analysis

Additional assays currently in development:

  • HER2
  • EGFR
  • KRAS
  • CTC/ctDNA combined profiling

We can also create custom solutions for numerous cancer types and liquid biopsy applications to meet your unique requirements.

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Two scientists in lab coats collaborating on a computer

Consult with our scientists to identify the most efficient and effective strategy to meet your project needs

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Standardized assay development and custom solutions

Our standardized workflow makes ctDNA, epithelial and mesenchymal CTCs and CTC clusters accessible for downstream analysis. Comprehensive profiling of liquid biopsy samples for drug relevant biomarkers allow longitudinal monitoring of patients to determine:

  • Which patients are suitable for a clinical trial?
  • Is the drug reaching the intended target and inducing the intended response?
  • To what extent is the drug having an impact on the cancer?

Our expert team provides an outsourced solution for the customized analysis of your samples and a service that is tailored to your specifications.

An extension to your team

Providing global support from our GCP-compliant laboratory, our multidisciplinary team of clinical and scientific experts have many years of experience in CTC analysis. We will work with you to provide the best solution for your project including optimized and standardized workflows to ensure an efficient process and reproducible results.

 Brett Swansiger - Chief Commercial Officer

Brett Swansiger

Chief Commercial Officer

Brett Swansiger is Chief Commercial Officer for ANGLE, and is responsible for managing pharma and clinical services sales and building corporate partnerships globally, and for guiding US research and clinical sales and payer engagement. He also supports the products business teams responsible for sale of products via direct sales and through distributors.

Brett has over 20 years of commercial leadership, international business development, business to business sales, and U.S. managed care contracting experience within the molecular diagnostics and pharmaceutical industries.

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 Bruno Gomes Machado - Clinical Laboratory Supervisor-Europe

Bruno Gomes Machado

Clinical Laboratory Manager

Bruno Machado joined ANGLE in 2021 as the Supervisor of ANGLE Clinical Lab UK. Bruno holds a BSc in Biomedical Sciences in Histocellular Pathology, is a Licentiate member of the Institute of Biomedical Science and is undergoing Management Training under the American Society for Clinical Pathology.

Bruno graduated in Portugal in 2014 and started working shortly after in Cellular Pathology for both the public and the private sectors in the UK. It was his longstanding position in cytology for a major healthcare provider in London that brought invaluable experience of a high-profile medical lab undergoing ISO15189 accreditation.

As well as a deep understanding of the importance of quality and prioritization in a complex sample management system, Bruno has also has a profound appreciation for the impact his work has on patient care, due to time spent in rapid onsite evaluations at both bedside FNA and theatre-based EBUS.

 Brett Swansiger - Chief Commercial Officer

Brett Swansiger

Chief Commercial Officer

Brett Swansiger is Chief Commercial Officer for ANGLE, and is responsible for managing pharma and clinical services sales and building corporate partnerships globally, and for guiding US research and clinical sales and payer engagement. He also supports the products business teams responsible for sale of products via direct sales and through distributors.

Brett has over 20 years of commercial leadership, international business development, business to business sales, and U.S. managed care contracting experience within the molecular diagnostics and pharmaceutical industries.

Read full bio
 Bruno Gomes Machado - Clinical Laboratory Supervisor-Europe

Bruno Gomes Machado

Clinical Laboratory Manager

Bruno Machado joined ANGLE in 2021 as the Supervisor of ANGLE Clinical Lab UK. Bruno holds a BSc in Biomedical Sciences in Histocellular Pathology, is a Licentiate member of the Institute of Biomedical Science and is undergoing Management Training under the American Society for Clinical Pathology.

Bruno graduated in Portugal in 2014 and started working shortly after in Cellular Pathology for both the public and the private sectors in the UK. It was his longstanding position in cytology for a major healthcare provider in London that brought invaluable experience of a high-profile medical lab undergoing ISO15189 accreditation.

As well as a deep understanding of the importance of quality and prioritization in a complex sample management system, Bruno has also has a profound appreciation for the impact his work has on patient care, due to time spent in rapid onsite evaluations at both bedside FNA and theatre-based EBUS.

Research Use Only. Not for use in Diagnostic Procedures

Discover how ANGLE can help with your liquid biopsy needs

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