ANGLE’s clinical laboratory provides specialised circulating tumour cell (CTC) enrichment and analysis services
Our mission is to advance the development of new cancer therapies and personalised medicine
We use Parsortix technology to harvest CTCs and CTCs clusters for subsequent DNA, RNA and protein expression analysis
Our team will work with you to ensure your success through all phases of your clinical trials
Currently offering the following standardised analyses:
- Enumeration of epithelial, mesenchymal and epithelial-to-mesenchymal transitioning (EMT) CTCs and CTC clusters
- DNA Damage Response (DDR) proteins
- PD-L1 protein expression analysis
Additional assays currently in development:
- HER2
- EGFR
- KRAS
- CTC/ctDNA combined profiling
We can also create custom solutions for numerous cancer types and liquid biopsy applications to meet your unique requirements.
Contact us
Consult with our scientists to identify the most efficient and effective strategy to meet your project needs
Contact usStandardised assay development and custom solutions
Our standardised workflow makes ctDNA, epithelial and mesenchymal CTCs and CTC clusters accessible for downstream analysis. Comprehensive profiling of liquid biopsy samples for drug relevant biomarkers allow longitudinal monitoring of patients to determine:
- Which patients are suitable for a clinical trial?
- Is the drug reaching the intended target and inducing the intended response?
- To what extent is the drug having an impact on the cancer?
Our expert team provides an outsourced solution for the customised analysis of your samples and a service that is tailored to your specifications.
An extension to your team
Providing global support from our GCP-compliant laboratory, our multidisciplinary team of clinical and scientific experts have many years of experience in CTC analysis. We will work with you to provide the best solution for your project including optimised and standardised workflows to ensure an efficient process and reproducible results.
Meet our laboratory services team
Brett Swansiger
Chief Commercial Officer
Brett Swansiger is Chief Commercial Officer for ANGLE, and is responsible for managing pharma and clinical services sales and building corporate partnerships globally, and for guiding US research and clinical sales and payer engagement. He also supports the products business teams responsible for sale of products via direct sales and through distributors.
Brett has over 20 years of commercial leadership, international business development, business to business sales, and U.S. managed care contracting experience within the molecular diagnostics and pharmaceutical industries.
Read full bio
Bruno Gomes Machado
Clinical Laboratory Manager
Bruno Machado joined ANGLE in 2021 as the Supervisor of ANGLE Clinical Lab UK. Bruno holds a BSc in Biomedical Sciences in Histocellular Pathology, is a Licentiate member of the Institute of Biomedical Science and is undergoing Management Training under the American Society for Clinical Pathology.
Bruno graduated in Portugal in 2014 and started working shortly after in Cellular Pathology for both the public and the private sectors in the UK. It was his longstanding position in cytology for a major healthcare provider in London that brought invaluable experience of a high-profile medical lab undergoing ISO15189 accreditation.
As well as a deep understanding of the importance of quality and prioritisation in a complex sample management system, Bruno has also has a profound appreciation for the impact his work has on patient care, due to time spent in rapid onsite evaluations at both bedside FNA and theatre-based EBUS.
Brett Swansiger
Chief Commercial Officer
Brett Swansiger is Chief Commercial Officer for ANGLE, and is responsible for managing pharma and clinical services sales and building corporate partnerships globally, and for guiding US research and clinical sales and payer engagement. He also supports the products business teams responsible for sale of products via direct sales and through distributors.
Brett has over 20 years of commercial leadership, international business development, business to business sales, and U.S. managed care contracting experience within the molecular diagnostics and pharmaceutical industries.
Read full bio
Bruno Gomes Machado
Clinical Laboratory Manager
Bruno Machado joined ANGLE in 2021 as the Supervisor of ANGLE Clinical Lab UK. Bruno holds a BSc in Biomedical Sciences in Histocellular Pathology, is a Licentiate member of the Institute of Biomedical Science and is undergoing Management Training under the American Society for Clinical Pathology.
Bruno graduated in Portugal in 2014 and started working shortly after in Cellular Pathology for both the public and the private sectors in the UK. It was his longstanding position in cytology for a major healthcare provider in London that brought invaluable experience of a high-profile medical lab undergoing ISO15189 accreditation.
As well as a deep understanding of the importance of quality and prioritisation in a complex sample management system, Bruno has also has a profound appreciation for the impact his work has on patient care, due to time spent in rapid onsite evaluations at both bedside FNA and theatre-based EBUS.
Research Use Only. Not for use in Diagnostic Procedures