Scientist I

ANGLE is a world-leading liquid biopsy company commercialising a patent protected platform technology that can capture rare circulating tumour cells (CTCs) from blood, in a minimally invasive way, for downstream analysis.

ANGLE’s Parsortix® system is FDA cleared for its intended use in metastatic breast cancer and is currently the first and only FDA cleared medical device to harvest intact circulating cancer cells from blood. Parsortix technology comprises a microfluidic device that captures CTCs from blood based on their size and compressibility. CTCs are cancer cells that have detached from the primary tumour and entered the blood circulation, and they play a critical role in initiating metastasis. Once harvested, the CTCs can be comprehensively analysed to provide a wealth of information about the patient’s tumour, advancing cancer research and potentially personalized medicine. This technology has the potential to deliver profound improvements in clinical and health economic outcomes.​

ANGLE has established a CTC harvest and analysis service from our UK-based Clinical Laboratory based in Guildford for customers worldwide. In alignment with company priorities, we plan to rapidly expand our services to include molecular profiling of CTCs and ctDNA using digital PCR and NGS to add to our image-based assays.​

This is an exciting time at ANGLE and our team in Guildford are looking for a Scientist 1 (Cell Biology & Imaging) to contribute to the development of clinical diagnostic products.

At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading-edge translational research into clinical diagnostics. We promote a culture of collaboration and shared excellence while encouraging an open and honest exchange of ideas.

We are always in search of potential employees who share our vision and want to make a difference today. In your submission, please describe your background and what you can bring to our team along with attaching your resume.​

• ​Hands-on laboratory work, primarily in the area of Molecular Biology, including blood processing, Nucleic Acid extraction, PCR, NGS library prep and NGS processing
• Contribute to the writing of ESs and reports where relevant, and the writing and updating of SOPs when required.
• Responsible for data collection, recording, processing, analysis and reporting
• Responsible for on-time and on-budget delivery of work packages within a project, including timely reporting of progress on projects and on metrics to monitor and mitigate risk and to ensure product deadlines are met
• Provide scientific and technical support to projects
• Responsible for on-time delivery of project goals, including timely reporting of progress to ensure project deadlines are met
• Responsible for quality and regulatory compliance of work undertaken
• Independently keep a current base knowledge in relevant areas of scientific and technical research
• Manage the day-to-day running of assigned projects within the Quality Management System (ISO13485) and work to the New Product Development (NPD) operating procedure
• Undertake additional ad-hoc tasks as required

• Bachelor in Life Sciences with relevant laboratory experience or Masters in Life Sciences, with laboratory experience in Oncology or Molecular Biology (preferably gained in the in vitro diagnostics assay development/validation industry). Or, an equivalent combination of professional/relevant experience and formal education
• Demonstrated expertise and hands-on competency in nucleic acid extraction, RT-qPCR and NGS
• Manage and deliver product development projects to agreed performance specifications, on time and within budget
• Good report writing skills, with the ability to communicate results to technical and non-technical staff
• Experience working to strict quality standards such as Medical Device Regulations including, but not limited to, 21 CFR 820, ISO 13485, 93/42/EEC, IVD 98/79 EC, ISO14971, GMP, GLP, QSR. A strong understanding of the importance of accurate record-keeping within a strictly controlled quality system is essential
• Organisational skills and the ability to rapidly prioritise tasks in response to unexpected changes
• Strong team player
• Strong verbal and written communication skills
• Ability to multitask and prioritise to meet deadlines
• Ability to work both independently with minimal supervision as well as in a team environment
• An eye for detail and commitment to high-quality data
• A flexible, can-do approach to the requirements of the job​

Due to the nature of the role, our requirement is for this position to be Guildford-based, office hours, five days per week.

As a member of our highly skilled team you will receive opportunities for training and development and a competitive benefits package.

Please let us know if you require disability-related accommodation during the recruitment process so that we can work with you to meet your needs.

Furthermore, please be advised that if you submit an application to us for this position, your application and personal details will be processed in accordance with our Data Privacy Notice for Job Candidates.