Clinical Scientist Molecular

ANGLE is a world-leading liquid biopsy company commercialising a patent protected platform technology that can capture rare circulating tumour cells (CTCs) from blood, in a minimally invasive way, for downstream analysis.

ANGLE’s Parsortix® system is FDA cleared for its intended use in metastatic breast cancer and is currently the first and only FDA cleared medical device to harvest intact circulating cancer cells from blood. Parsortix technology comprises a microfluidic device that captures CTCs from blood based on their size and compressibility. CTCs are cancer cells that have detached from the primary tumour and entered the blood circulation, and they play a critical role in initiating metastasis. Once harvested, the CTCs can be comprehensively analysed to provide a wealth of information about the patient’s tumour, advancing cancer research and potentially personalized medicine. This technology has the potential to deliver profound improvements in clinical and health economic outcomes.

ANGLE has established a CTC harvest and analysis service from our UK-based Clinical Laboratory based in Guildford for customers worldwide. In alignment with company priorities, we plan to rapidly expand our services to include molecular profiling of CTCs and ctDNA using digital PCR and NGS to add to our image-based assays.

This is an exciting time at ANGLE and our team in Guildford are looking for a Clinical Scientist I (Molecular). ​The Scientist 1 will play a pivotal role in executing Next-Generation Sequencing (NGS) and digital PCR (dPCR) workflows within the Clinical Molecular Team. ​​

At ANGLE, we foster a dynamic, entrepreneurial approach to translating leading-edge translational research into clinical diagnostics. We promote a culture of collaboration and shared excellence while encouraging an open and honest exchange of ideas.

We are always in search of potential employees who share our vision and want to make a difference today. In your submission, please describe your background and what you can bring to our team along with attaching your resume.

This position is responsible for processing clinical samples, setting up and performing molecular assays, conducting necessary data analysis, performing quality control checks, and ensuring accurate and comprehensive documentation of all associated laboratory activities. The Scientist 1 will work to complete all tasks within the outlined turnaround times, collaborating closely with other scientists and laboratory staff within the Clinical Team to ensure the highest standards of accuracy, quality, and regulatory compliance. This includes a focus on meeting the requirements of ISO 15189:2022 for medical laboratories.

• Perform clinical sample processing, including human blood and other biological specimens, in strict adherence to established protocols and ISO 15189:2022 standards.
• Execute and troubleshoot DNA/RNA extraction, digital PCR, and next-generation sequencing (NGS) assays, ensuring high-quality, accurate results.
• Analyse and document experimental data, ensuring complete traceability, including sample processing, assay results, and equipment calibration.
• Operate and maintain laboratory instruments and equipment, ensuring optimal performance, troubleshooting as needed, and adhering to calibration schedules.
• Collaborate cross-functionally with clinical teams to optimize laboratory processes and resolve operational issues.
• Accurately enter and review laboratory data, ensuring compliance with regulatory standards for data integrity and traceability.
• Contribute to the training and development of new laboratory staff under the guidance of Senior Scientists and the Clinical Laboratory Director.
• Support daily laboratory operations as needed.
• Actively contribute to the continuous improvement of laboratory workflows to enhance operational efficiency.
• Promote a culture of safety and quality by adhering to all laboratory and organisational policies for health, safety, and environmental protection.
• Undertake additional ad-hoc tasks as required

• MSc/BSc in a relevant biomedical field
• 1-2 years of experience in a laboratory setting, preferably in molecular biology
• Experience with molecular techniques such as PCR, sequencing, DNA/RNA extraction, and other cell-based or molecular diagnostic methods
• Experience with good laboratory practices, data integrity and documentation practices in compliance with regulatory requirements
• Experience using laboratory information management systems (LIMS), data entry, and ensuring the accuracy and traceability of laboratory records preferred
• Familiarity with ISO 15189:2022 standards for medical laboratories preferred
• Detail oriented and commitment to high quality data
• A flexible, can-do approach to the requirements of the job

Due to the nature of the role, our requirement is for this position to be Guildford based, office hours, five days per week. As a member of our highly skilled team you will receive opportunities for training and development and a competitive benefits package.

Please let us know if you require disability-related accommodation during the recruitment process so that we can work with you to meet your needs.

Furthermore, please be advised that if you submit an application to us for this position, your application and personal details will be processed in accordance with our Data Privacy Notice for Job Candidates.