Onc-ADaPT laboratories provide specialized circulating tumor cell (CTC) enrichment and analysis services
Our mission is to advance the development of new cancer therapies and personalized medicine
We use Parsortix technology to harvest CTCs and CTCs clusters for subsequent DNA, RNA and protein expression analysis
Our team will work with you to ensure your success through all phases of your clinical trials
Currently offering the following standardized analyses:
- Enumeration of epithelial and mesenchymal CTCs and clusters
- DNA Damage Response (DDR) proteins
Additional assays are currently in development
We can also create custom solutions for numerous cancer types and liquid biopsy applications to meet your unique requirements
Contact us
Consult with our scientists to identify the most efficient and effective strategy to meet your project needs
Contact usStandardized assay development and custom solutions
Our standardized workflow makes ctDNA, epithelial and mesenchymal CTCs and CTC clusters accessible for downstream analysis. Comprehensive profiling of liquid biopsy samples for drug relevant biomarkers allow longitudinal monitoring of patients to determine:
- Which patients are suitable for a clinical trial?
- Is the drug reaching the intended target and inducing the intended response?
- To what extent is the drug having an impact on the cancer?
Our expert team provides an outsourced solution for the customized analysis of your samples and a service that is tailored to your specifications.
An extension to your team
Providing global support from our GCP-compliant labs in the UK and in North America, our multidisciplinary team of clinical and scientific experts have many years of experience in CTC analysis. We will work with you to provide the best solution for your project including optimized and standardized workflows to ensure an efficient process and reproducible results.
Madeline Repollet, PhD
Clinical Laboratories Director
Madeline Repollet joined ANGLE in 2020 as the Head of Clinical Laboratories. Dr. Repollet holds a PhD in Health Care Administration, a MS in Quality Assurance & Regulatory Affairs and a BS in Biology. She is Board Certified as a Cytotechnologist by the American Society for Clinical Pathology.
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Christina Barbato
Clinical Laboratory Supervisor-NA
Christina Barbato joined ANGLE in 2020 as a cytologist. In 2021, she was promoted to US Clinical Laboratory Supervisor. Christina holds an MS in Cytotechnology and Cell Sciences from Thomas Jefferson University. She is Board Certified as a Cytotechnologist by the American Society for Clinical Pathology (ASCP). During her studies Christina received Academic Achievement Award, and recognition at the Student Case Study Presentations at the 2017 American Society for Cytotechnology. In 2022 she received a Blue Ribbon Award for a poster presentation at the ASCP Conference. She is currently an Alumni Member of the Cytotechnology Advisory Committee at Jefferson University.
Christina brings years of experience in various clinical laboratory settings (including hospital and reference lab environments) to ANGLE. Her current clinical lab experience offers a true view of clinical laboratory instrumentation and assay requirements and needs in North America.
Read full bio
Bruno Gomes Machado
Clinical Laboratory Supervisor-Europe
Bruno Machado joined ANGLE in 2021 as the Supervisor of ANGLE Clinical Lab UK. Bruno holds a BSc in Biomedical Sciences in Histocellular Pathology, is a Licentiate member of the Institute of Biomedical Science and is undergoing Management Training under the American Society for Clinical Pathology.
Bruno graduated in Portugal in 2014 and started working shortly after in Cellular Pathology for both the public and the private sectors in the UK. It was his longstanding position in cytology for a major healthcare provider in London that brought invaluable experience of a high-profile medical lab undergoing ISO15189 accreditation.
As well as a deep understanding of the importance of quality and prioritization in a complex sample management system, Bruno has also has a profound appreciation for the impact his work has on patient care, due to time spent in rapid onsite evaluations at both bedside FNA and theatre-based EBUS.
Frank Smith
Business Development
Frank Smith is responsible for managing ANGLE’s biopharma and clinical testing service sales and building corporate partnerships for all lines of business outside of North America.
Frank has over 25 years of commercial experience leading business development and product management teams within the life science industry; particularly, molecular diagnostics and medical devices. Frank, has a very broad technical understanding of Translational Research, Precision Medicine, the “Omics” analytical markets, bioinformatics and the importance of the preanalytical phase to provide high quality samples for clinical analysis and biopharma research. Throughout his career he has been driven by his desire help scientists and clinicians achieve their respective goals to improve patient outcomes by providing clinicians better and more complete patient data for informed decision making.
Read full bio
Madeline Repollet, PhD
Clinical Laboratories Director
Madeline Repollet joined ANGLE in 2020 as the Head of Clinical Laboratories. Dr. Repollet holds a PhD in Health Care Administration, a MS in Quality Assurance & Regulatory Affairs and a BS in Biology. She is Board Certified as a Cytotechnologist by the American Society for Clinical Pathology.
Read full bio
Christina Barbato
Clinical Laboratory Supervisor-NA
Christina Barbato joined ANGLE in 2020 as a cytologist. In 2021, she was promoted to US Clinical Laboratory Supervisor. Christina holds an MS in Cytotechnology and Cell Sciences from Thomas Jefferson University. She is Board Certified as a Cytotechnologist by the American Society for Clinical Pathology (ASCP). During her studies Christina received Academic Achievement Award, and recognition at the Student Case Study Presentations at the 2017 American Society for Cytotechnology. In 2022 she received a Blue Ribbon Award for a poster presentation at the ASCP Conference. She is currently an Alumni Member of the Cytotechnology Advisory Committee at Jefferson University.
Christina brings years of experience in various clinical laboratory settings (including hospital and reference lab environments) to ANGLE. Her current clinical lab experience offers a true view of clinical laboratory instrumentation and assay requirements and needs in North America.
Read full bio
Bruno Gomes Machado
Clinical Laboratory Supervisor-Europe
Bruno Machado joined ANGLE in 2021 as the Supervisor of ANGLE Clinical Lab UK. Bruno holds a BSc in Biomedical Sciences in Histocellular Pathology, is a Licentiate member of the Institute of Biomedical Science and is undergoing Management Training under the American Society for Clinical Pathology.
Bruno graduated in Portugal in 2014 and started working shortly after in Cellular Pathology for both the public and the private sectors in the UK. It was his longstanding position in cytology for a major healthcare provider in London that brought invaluable experience of a high-profile medical lab undergoing ISO15189 accreditation.
As well as a deep understanding of the importance of quality and prioritization in a complex sample management system, Bruno has also has a profound appreciation for the impact his work has on patient care, due to time spent in rapid onsite evaluations at both bedside FNA and theatre-based EBUS.
Frank Smith
Business Development
Frank Smith is responsible for managing ANGLE’s biopharma and clinical testing service sales and building corporate partnerships for all lines of business outside of North America.
Frank has over 25 years of commercial experience leading business development and product management teams within the life science industry; particularly, molecular diagnostics and medical devices. Frank, has a very broad technical understanding of Translational Research, Precision Medicine, the “Omics” analytical markets, bioinformatics and the importance of the preanalytical phase to provide high quality samples for clinical analysis and biopharma research. Throughout his career he has been driven by his desire help scientists and clinicians achieve their respective goals to improve patient outcomes by providing clinicians better and more complete patient data for informed decision making.
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