Portrait®PD-L1

Optimise your cancer therapy trials

Streamline patient selection with the Portrait PD-L1 testing solution

A novel approach for evaluating the expression of PD-L1 on circulating tumour cells (CTCs)

Blood sample collection tubes in a rack
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Send your whole blood samples to our laboratory.

A graphic representation of CTC harvesting in action
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We use ANGLE’s Parsortix technology to isolate and enrich epithelial, mesenchymal, and epithelial-to-mesenchymal transition (EMT) CTCs.

Portrait®PD-L1 - Optimize your cancer therapy trials
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We harvest, enumerate and characterise the CTCs using our Portrait PD-L1 test.

A man and woman collaborating on a laptop engaged in work
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You receive a detailed report of your results.

Portrait PD-L1 can help investigate the mechanisms of cancer progression and evolution

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Why choose Portrait PD-L1?

The test…

ANGLE’s Portrait PD-L1 service is an end-to-end solution using cutting edge CTC technology with the potential to facilitate:

  • Minimally invasive liquid biopsy with sample stability out to 5 days post collection
  • Identification and enumeration of CTCs
  • Highly accurate, repeatable, and precise PD-L1 CTC results
  • Early competitive advantage by understanding therapeutic response sooner
  • Optimised patient selection
  • Reduced trial size, costs and time
  • Longitudinal monitoring of PD-L1 status on phenotypic variety of CTCs

The service…

ANGLE’s extensive experience in CTC testing, combined with our global presence, ensures:

  • Exceptional data quality and timely reporting
  • Global clinical study support
  • Flexibility to accommodate your clinical study schedule

Portrait PD-L1 analytical sensitivity and analytical specificity*

Key performance metrics using epithelial HCC1954 (epithelial) and Hs 578T (mesenchymal) cell lines spiked and recovered from peripheral blood using Parsortix technology.

PD-L1

80%

Analytical Sensitivity

PD-L1

98%

Analytical Specificity

Epithelial
Markers

98%

Analytical Sensitivity

Epithelial
Markers

99%

Analytical Specificity

Mesenchymal
Markers

97%

Analytical Sensitivity

Mesenchymal
Markers

92%

Analytical Specificity

Representative staining of a CTC cluster from a lung cancer patient

Representative staining of a CTC cluster from a lung cancer patient

Mesenchymal CTCs isolated using Parsortix technology from a lung cancer patient and stained with the Portrait Flex assay with additional PD-L1 marker. CTCs show PD-L1 expression (purple = mesenchymal markers, green= epithelial markers, orange = PD-L 1, blue = nucleus, and red = blood lineage markers (white in merged image)).

Ask how else we can help you

ANGLE’s clinical laboratory offers a suite of complementary CTC enrichment and analysis solutions to enhance your cancer therapy clinical studies.

 

For example, why not consider adding DNA Damage Response (DDR) assessment in CTCs to your Portrait PD-L1 service?

Portrait PD-L1 may help stratify or identify suitable patients for your clinical trial.
DDR (measured via yH2AX and pKAP1 expression) may be used to monitor the drug or therapy’s efficacy by showing double strand breaks on heterogeneous CTCs.
Together, these markers could potentially help guide expansion of the patient population eligible for targeted therapy (PDL1 +/-) and then longitudinally monitor both PD- L1 and DDR status to evaluate therapy efficacy.

For Research Use Only. Not For Use in Diagnostic Procedures.

Portrait PD-L1 – the full-service solution to help unlock precision medicine for your patients

Interested in knowing how Portrait PD-L1 can help with your clinical trial testing? Leave your name and email address and we will be in touch with more information.

    *Analytical Sensitivity = proportion of spiked cells known to express the marker(s) of interest which were marker positive in the assay. Analytical Specificity = proportion of spiked cells known to NOT express the marker(s) of interest which were marker negative in the assay.

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